Vas Deferens

Vas Deferens Definition

The Vas Deference or Ductus deferens is a thin, fibromuscular tube initiating from the epididymis and converting into the ejaculatory duct in the male reproductive system. Being 30-45cm long and less than 5mm in diameter, it serves in transporting sperm cells from each of the testis to the common ejaculatory duct.

Vas Deferens Location

The tube is a highly convoluted structure while extending from the globus minor, which straightens up as it ascends medial to the epididymis and joins other juxtaposed structures of the spermatic cord while extending into the inguinal canal. In the pelvic space, the ductus deferens is seen passing anterior to the pelvic bone, turning at right angles over the pelvic brim nearing the urinary bladder. Running superior to the ureters, it then ascends along the posterior side of the bladder towards the prostate gland, where the ductus deferens expands fairly forming an ampulla before it narrows again and joins the seminal vesicles to form the large, ejaculatory duct. Each duct has an artery branching from the superior vesicle artery, converting into the venous drainage to the pelvic venous plexus. Lymphatic drainage goes towards both external and internal iliac nodes. Its innervation arises from the pelvic plexus and is sympathetic in nature.

Location of Vas Deferens

Vas Deferens Location

Vas Deferens: Histology

The vas deferens is made up of 3 layers:

  • Outer layer
  • Middle muscular layer
  • Internal mucous layer

The middle layer is made up of smooth muscle fibers from the outside and circular muscles from the inside, making the middle layer thicker than the diameter of the lumen. The proximal part of the duct further differentiates these two layers into outer and inner layers made up of longitudinal smooth muscles and another middle layer consisting of the circular muscle fibers.  Reaching towards the inguinal canal the innermost layer of longitudinal muscle fibers get eliminated. This 1.5m thick muscular layer is lined with the mucous layer, made up of pseudostratified columnar epithelial cells, having anterior stereocilia that help the sperm cells to move smoothly throughout the tube; providing a protective covering to the lumen. The diameter of the lumen is 2.5mm.

Vas Deferens Function

The Vas Deferens is a 30cm long tube whose main function is to transport sperms that are mature and which reside in the epididymis, towards the urethra, when the body is ready for ejaculation. The sperm is pushed to the urethra by peristaltic motion. Through its way out, sperm mixes with secretions of the bulbourethral gland and the prostate gland, and also that of the seminal vesicles.

Vas Deferens Pictures

Images of Vas Deferens

Picture of Vas Deferens

Medical Conditions Associated With Vas Deferens

As vas deferens is the duct responsible for transmission of sperm cells to the ejaculatory system of the male reproductive system, severe medical conditions can lead to complete sterility of the individual.


The most common vas deferens issue is the Congenital Absence of Vas Deferens.  Being a genetic disorder, this medical condition is prevalent from the child’s birth. The individual’s reproductive system is capable of producing active sperm cells but, unable to push the sperm towards the ejaculatory duct, making the semen sperm less. Reproduction is only possible through collecting the sperm through surgery and in vitro fertility processes.

Obstructive Azoospermia

Azoospermia is the complete absence of sperm in semen, which happens as a result of a blockage or obstruction present in the vas deferens which might have resulted as a post-surgical effect, as a result of a repairing hernia, etc. Surgical treatment for this problem is possible with the recovery of up to 65%.

Causes for Blockage of Vas Deferens

  • Congenital anomalies: Patient can be suggested for a recanalization surgery.
  • Inflammatory stenosis: Bacterial infection, generally arising from infected testis or epididymitis can cause inflammation, irritation, scarring, lesion, luminal occultation, etc. which leads to obstructive azoospermia. The infection is eliminated through drugs and recanalization is considered if needed.
  • Tumor: Tumor formation can take place if vas deferens or the nearby organs such as seminal vesicle, spermatic cord, prostate gland, etc. are at a stage of metastasis. Cyst or tumor so produced, and obstructing the duct, can be surgically removed.
  • Surgical Trauma: Surgery around the vas deferens can lead to erroneous snipping of the duct leading to obstruction in the vas deferens.

Symptoms of Blockage of Vas Deferens

  • The patient has clinical findings of infertility, history of infertility, reduced erectly sensation, ejaculatory pain or weakness.
  • The patient may have infected reproductive tract, error barred surgical history
  • Physical examination of the epididymis or vas deferens shows changes in touch nodules, thickness, cysts, etc.


It is the clinical condition of infective and sometimes inflammative symptoms of the epididymis, caused by bacterial pathogens like Mycobacterium tuberculosis (TB). It occurs mostly in men between the ages of 20-39. In children, it can be caused due to infective traumatic injury. However, in some rare conditions, it can occur due to child abuse.

Symptoms of  Epididymitis

  • The individual experiences pain in the groin
  • Fever
  • Blood in urine, penile discharge, blood in semen
  • Pain during ejaculation
  • Painful scrotal swelling

Treatment of  Epididymitis

  • Administration of appropriate drugs is required to eliminate the disease.
  • Sexually transmitted infections require antibiotics as well as treatment of the sexual partner.
  • Effective pain-killers may also be suggested.
  • Planned follow-up with the medical practitioner is required to assure complete elimination of the disease.

Prevention of Epididymitis

  • Prevention is possible if the disease is diagnosed early.
  • Antibiotics should be taken after surgery
  • Safe sex should be practiced.
  • Multiple sexual partners should be avoided

Last updated on February 4th, 2018 at 1:37 pm

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